PITTSBURGH 1 – CHICAGO 0 
Win: Bryan Morris (1-0)
L: Carlos Villanueva (0-1)
— Neil Walker homered off Carlos Villanueva in the bottom of the 10th, lifting the Pittsburgh Pirates to a 1-0 walk off win over the Chicago Cubs on opening day. On a 3-2 count, Walker took the 8th pitch of the at-bat he saw deep and over the Clemente Wall for the Pirates first opening day walkoff homer since Bob Bailey in 1965. The walkoff homer was Walker’s first of his career.
— Francisco Liriano had electric stuff, throwing six scoreless innings, striking out 10 and walking 3. He allowed 4 hits. Liriano, Mark Melancon, Tony Watson, Jason Grilli and Bryan Morris combined for 10 scoreless innings as the Pirates allowed just 5 hits in the game.
— Bryan Morris got the win throwing a scoreless 10th inning. The Pirates were the benefit of an overturned call in the 10th due to the new rules in place.
— Travis Ishikawa was 2-3 in his Pirates debut. Ishikawa was the Pirates only player with multi-hits in the game. Pittsburgh managed 6 hits in the game.