The Panthers (19-8, 8-7) have fallen to 0-6 vs ranked teams as No. 11 Louisville (22-6, 11-4) pulled away in the final minutes to secure a 67-60 victory on Wednesday night.
Ryan Luther finished with a career-high 17 points, Jamel Artis had 13 points and nine rebounds for the Panthers. Pitt shot 42% (21-50) in the game, including 22% from three-point range. Louisville shot 44% (7-16) from three.
Next up for the Panthers is No. 15 Duke on Sunday.